Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1-Reference-Cited by-同舟云学术

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1

Published:1990-10 Issue:10 Volume:64 Page:5226-5229
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lu Y C¹,Touzjian N¹,Stenzel M¹,Dorfman T¹,Sodroski J G¹,Haseltine W A¹

Affiliation:

1. Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Abstract

The negative regulatory element of human immunodeficiency virus type 1 is a 260-nucleotide-long sequence that decreases the rate of RNA transcription initiation specified by the long terminal repeat. This region has the potential to bind several cellular transcription factors. Here it is shown that sequences which recognize the NFAT-1 and USF cellular transcription factors contribute to this negative regulatory effect. The sequences within the negative regulatory element which resemble the AP-1 site and the URS do not negatively regulate human immunodeficiency virus long terminal repeat transcription initiation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.64.10.5226-5229.1990

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