Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion-Reference-Cited by-同舟云学术

Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Imwong Mallika¹²^ORCID,Suwannasin Kanokon²,Srisutham Suttipat³,Vongpromek Ranitha⁴,Promnarate Cholrawee⁴,Saejeng Aungkana⁵,Phyo Aung Pyae⁶^ORCID,Proux Stephane⁷,Pongvongsa Tiengkham⁸,Chea Nguon⁹,Miotto Olivo²¹⁰¹¹,Tripura Rupam²¹¹,Nguyen Hoang Chau¹²,Dysoley Lek⁹,Ho Dang Trung Nghia¹²,Peto Thomas J.²¹¹,Callery James J.²,van der Pluijm Rob W.²,Amaratunga Chanaki²¹¹,Mukaka Mavuto²¹¹,von Seidlein Lorenz²¹¹,Mayxay Mayfong¹¹¹³¹⁴,Thuy-Nhien Nguyen Thanh¹²,Newton Paul N.¹¹,Day Nicholas P. J.²¹¹,Ashley Elizabeth A.¹¹¹⁴,Nosten Francois H.⁷¹¹,Smithuis Frank M.⁶¹¹,Dhorda Mehul²³¹¹,White Nicholas J.²¹¹,Dondorp Arjen M.²¹¹

Affiliation:

1. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand

4. Worldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

5. Division of Vector-Borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand

6. Myanmar Oxford Clinical Research Unit, Yangon, Myanmar

7. Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand

8. Savannakhet Provincial Health Department, Savannakhet, Lao People’s Democratic Republic

9. National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia

10. Wellcome Sanger Institute, Hinxton, United Kingdom

11. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

12. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

13. Institute of Research and Education Development, University of Health Sciences, Ministry of Health, Vientiane, Lao People’s Democratic Republic

14. Lao–Oxford–Mahosot Hospital–Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People’s Democratic Republic

Abstract

Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion.

Funder

Wellcome

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01121-21

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