Emerging Terbinafine Resistance in Trichophyton : Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection-Reference-Cited by-同舟云学术

Emerging Terbinafine Resistance in Trichophyton : Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Saunte Ditte M. L.¹²³^ORCID,Hare Rasmus K.²^ORCID,Jørgensen Karin M.²,Jørgensen René²^ORCID,Deleuran Mette⁴,Zachariae Claus O.⁵,Thomsen Simon F.⁶⁷,Bjørnskov-Halkier Lars⁸,Kofoed Kristian⁵,Arendrup Maiken C.²³⁹^ORCID

Affiliation:

1. Department of Dermatology, Zealand University Hospital, Roskilde, Denmark

2. Unit of Mycology, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark

3. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

4. Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark

5. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

6. Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark

7. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

8. Dermatologic Clinic, Horsens, Denmark

9. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

Abstract

In recent years, cases involving terbinafine-resistant Trichophyton isolates have been reported increasingly, particularly in India. We present 14 cases of terbinafine treatment failure in Trichophyton -infected Danish patients due to acquired resistance. Patients infected with Trichophyton rubrum ( n = 12) or Trichophyton interdigitale ( n = 2) with elevated terbinafine MICs during 2013–2018 were included.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01126-19

Reference28 articles.

1. Activity of TDT 067 (Terbinafine in Transfersome) against Agents of Onychomycosis, as Determined by Minimum Inhibitory and Fungicidal Concentrations

2. Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene

3. OUP accepted manuscript

4. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene

5. New Antifungal Agents and New Formulations Against Dermatophytes

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