The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae Responds to Carbonyl Stress and Modulates Hydrogen Peroxide Production-Reference-Cited by-同舟云学术

The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae Responds to Carbonyl Stress and Modulates Hydrogen Peroxide Production

Published:2010-08 Issue:15 Volume:192 Page:4063-4066
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Potter Adam J.¹,Kidd Stephen P.¹,McEwan Alastair G.²,Paton James C.¹

Affiliation:

1. School of Molecular and Biomedical Science, University of Adelaide, Adelaide 5005, South Australia, Australia

2. School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia 4072, Queensland, Australia

Abstract

ABSTRACT The NmlR sp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlR sp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlR sp strain exhibits increased resistance to high oxygen tension, attributable to decreased H 2 O 2 production, which correlated with downregulation of carbamoyl phosphate synthase ( carB ). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlR sp in the regulation of carbon metabolism.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00383-10

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