Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khalil Zeinab G.¹²,Hill Timothy A.³,De Leon Rodriguez Luis M.⁴,Lohman Rink-Jan³,Hoang Huy N.³,Reiling Norbert⁵⁶,Hillemann Doris⁷,Brimble Margaret A.⁴⁸,Fairlie David P.³,Blumenthal Antje²,Capon Robert J.¹

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

2. The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

3. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

4. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand

5. Research Center Borstel, Leibniz Lung Center, Borstel, Germany

6. German Center for Infection Research (DZIF), Borstel Site, Borstel, Germany

7. National and Supranational Reference Laboratory, Leibniz Lung Center, Borstel, Germany

8. School of Chemical Sciences and School of Biological Sciences, The University of Auckland, Auckland, New Zealand

Abstract

Wollamides are cyclic hexapeptides, recently isolated from an Australian soil Streptomyces isolate, that exhibit promising in vitro antimycobacterial activity against Mycobacterium bovis Bacille Calmette Guérin without displaying cytotoxicity against a panel of mammalian cells. Here, we report the synthesis and antimycobacterial activity of 36 new synthetic wollamides, collated with all known synthetic and natural wollamides, to reveal structure characteristics responsible for in vitro growth-inhibitory activity against Mycobacterium tuberculosis (H37Rv, H37Ra, CDC1551, HN878, and HN353).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01773-18

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