The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch-Reference-Cited by-同舟云学术

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

Published:2021-02-23 Issue:3 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kawashima Agnieszka T.¹²,Wong Cassandra³,Lordén Gema¹,King Charles C.⁴,Lara-Gonzalez Pablo⁵,Desai Arshad⁵,Gingras Anne-Claude³⁶,Newton Alexandra C.¹

Affiliation:

1. Department of Pharmacology, University of California, San Diego, California, USA

2. Biomedical Sciences Graduate Program, University of California, San Diego, California, USA

3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

4. Department of Pediatrics, University of California, San Diego, California, USA

5. Department of Cellular and Molecular Medicine, University of California, San Diego, California, USA

6. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Abstract

PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a tumor suppressor that directly dephosphorylates a wide array of substrates, most notably the prosurvival kinase Akt. However, little is known about the molecular mechanisms governing PHLPP1 itself.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00333-20

Reference84 articles.

1. Aneuploidy in Cancer and Aging