Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride-Reference-Cited by-同舟云学术

Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride

Published:2021-02-23 Issue:3 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bader Deena¹,Patel Rekha S.¹,Lui Ashley²,Thawani Chetna³,Rupani Rea⁴,Vidyarthi Gitanjali¹,Patel Niketa A.¹²^ORCID

Affiliation:

1. James A. Haley Veterans Hospital, Research Service, Tampa, Florida, USA

2. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

3. Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

4. Honors College, University of South Florida, Tampa, Florida, USA

Abstract

Lithium chloride (LiCl) is commonly used in treatment of mood disorders; however, its usage leads to weight gain, which promotes metabolic disorders. Protein kinase C delta (PKCδ), a serine/threonine kinase, is alternatively spliced to PKCδI and PKCδII in 3T3-L1 cells.

Funder

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00338-20

Reference68 articles.

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2. Weight Gain with Lithium

3. Dysregulated Alternative Splicing Pattern of PKCδ during Differentiation of Human Preadipocytes Represents Distinct Differences between Lean and Obese Adipocytes

4. Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line

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