Affiliation:
1. Department of Biochemistry, State University of New York, Stony Brook, New York 11790
Abstract
A strain of
Salmonella typhimurium
, MF1680, was isolated that required isoleucine for normal growth at 37 C but not at 27 C. In minimal medium the growth of MF1680 was strongly blocked by valine. Growth inhibition was reversed by isoleucine. When this mutant was grown at 37 C, the form of acetohydroxy acid synthetase not inhibited by valine, (AHAS
R
), could not be detected. The site of this mutation in AHAS
R
, termed
ilvG
, was found to map in the
ilv
gene cluster between
ilvD
and
ilvE
.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
23 articles.
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