Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor)

Author:

Yarkoni E,Rapp H J

Abstract

Susceptibility to the lethal toxicity of endotoxin in mice pretreated with emulsified trehalose-6,6'-dimycolate was enhanced by (i) increasing the oil concentration while keeping the Tween concentration constant; and (ii) decreasing the Tween concentration, while keeping the oil concentration constant.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference10 articles.

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2. Enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate);Parant M.;J. Infect. Dis.,1977

3. A simple method of estimating 50% endpoints;Reed L J;Am. J. Hyg.,1938

4. Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions;Suter E.;Immunology,1961

5. Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid;Yarkoni E.;Infect. Immun.,1979

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