Author:
Männel D N,Rosenstreich D L,Mergenhagen S E
Abstract
Lipopolysaccharide (LPS) induces rapid necrosis of intradermal fibrosarcomas in mice. The mechanism(s) by which LPS produces tumor necrosis has been investigated using histocompatible LPS-sensitive (C3H/HeN) and LPS-resistant (C3H/HeJ) mouse strains. C3H/HeN- or C3H/HeJ-derived fibrosarcomas were necrotized by LPS when they were grafted onto C3H/HeN mice but were not affected when growing on C3H/HeJ mice, indicating that LPS does not act directly on the tumor itself. In contrast, lethally X-irradiated C3H/HeJ mice exhibit necrosis of their tumors when reconstituted with C3H/HeN bone marrow cells, whereas C3H/HeN mice no longer exert LPS-induced tumor necrosis after the adoptive transfer of C3H/HeJ bone marrow cells. These findings clearly indicate that LPS produces necrosis of tumors by activating host lymphoreticular cells.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference16 articles.
1. Vascular reactions of normal and malignant tissues in vivo. V. Role of hypotension in action of bacterial polysaccharide on tumors;Algire G. H.;J. Natl. Cancer Inst.,1952
2. Suppression of murine tumor growth by immune reaction to the Bacillus Calmette-Guerin strain of Mycobacterium bovis;Bartlett G. L.;J. Natl. Cancer Inst.,1972
3. Requirement for a radiosensitive Iymphoid cell in the generation of lipopolysaccharide-induced rejection of a murine tumor allograft;Berendt M. J.;Infect. Immun.,1978
4. Bliss C. I. 1967. Fischer's exact test for 2 x 2 tables p. 63-65. In C. I. Bliss (ed.) Statistics in biology vol. 3. McGraw-Hill Book Company Inc. New York.
5. Immunologic and antineoplastic effects of endotoxin: role of membranes and mediation by cyclic adenosine-3',5'-monophosphate;Braun W.;J. Infect. Dis.,1973
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