Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4 + T EM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice

Author:

Srivastava Ruchi1,Coulon Pierre-Gregoire A.1,Prakash Swayam1,Dhanushkodi Nisha R.1,Roy Soumyabrata1,Nguyen Angela M.1,Alomari Nuha I.1,Mai Uyen T.1,Amezquita Cassendra1,Ye Caitlin1,Maillère Bernard2,BenMohamed Lbachir134

Affiliation:

1. Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA

2. Commissariat à l’Energie Atomique et aux Energies Alternatives-Saclay, Université Paris-Saclay, Service d’Ingénierie Moléculaire des Protéines, Gif-sur-Yvette, France

3. Department of Molecular Biology and Biochemistry, University of California Irvine, School of Medicine, Irvine, California, USA

4. Institute for Immunology, University of California Irvine, School of Medicine, Irvine, California, USA

Abstract

We report that naturally protected HSV-1-seropositive asymptomatic individuals develop a higher frequency of antiviral effector memory CD4 + T EM cells specific to two immunodominant epitopes derived from the HSV-1 tegument protein VP11/12. Immunization of HLA-DR transgenic mice with a mixture of these two immunodominant CD4 + T cell epitopes induced a robust antiviral CD4 + T cell response in the cornea that was associated with protective immunity against ocular herpes. The emerging concept of developing an asymptomatic herpes vaccine that would boost effector memory CD4 + and CD8 + T EM cell responses is discussed.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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