Affiliation:
1. Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Abstract
The antibiotics congocidine and distamycin A inhibited the replication of Shope fibroma and vaccinia viruses in BSC
1
cells. Treatment of infected cultures with congocidine for a 12-hr period resulted in an irreversible inhibitory effect on virus development. A longer period of treatment with the antibiotic also resulted in inhibition of the residual infectious virions present in the treated cells. Distamycin A inhibited the replication of poxviruses, but its inhibitory effect was reversed when the antibiotic was removed from the infected cells even as long as 24 hr after treatment. The inhibitory effect of distamycin A and its reversibility resembled the antipoxvirus activity of rifampin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
13 articles.
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