Curcumin-Artemisinin Combination Therapy for Malaria

Author:

Nandakumar Dalavaikodihalli Nanjaiah1,Nagaraj Viswanathan Arun1,Vathsala Palakkod Govindan1,Rangarajan Pundi1,Padmanaban Govindarajan1

Affiliation:

1. Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India

Abstract

ABSTRACT Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of α,β-arteether to Plasmodium berghei -infected mice are able to prevent recrudescence due to α,β-arteether monotherapy and ensure almost 100% survival of the animals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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