Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates-Reference-Cited by-同舟云学术

Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates

Published:2006-05 Issue:5 Volume:50 Page:1900-1902
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Plinke Claudia¹,Rüsch-Gerdes Sabine¹,Niemann Stefan¹

Affiliation:

1. Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany

Abstract

ABSTRACT We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 ( embB 306). Mutations were detected only in EMB-resistant strains ( n = 69; 68%), thus confirming the significance of embB 306 mutations for the prediction of resistance to EMB.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.5.1900-1902.2006

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