Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients-Reference-Cited by-同舟云学术

Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients

Published:2008-02 Issue:2 Volume:15 Page:379-381
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Stayoussef Mouna¹²³⁴,Al-Jenaidi Fayza A.¹²³⁴,Al-Abbasi Abduljabbar¹²³⁴,Al-Ola Khadija¹²³⁴,Khayyat Haya¹²³⁴,Mahjoub Touhami¹²³⁴,Almawi Wassim Y.¹²³⁴

Affiliation:

1. University of Monastir, Monastir, Tunisia

2. College of Medicine and Medical Sciences, Arabian Gulf University

3. Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain

4. Bahrain Defense Forces Hospital, Rifaa, Bahrain

Abstract

ABSTRACT Tumor necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00410-07

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