Persistence of Virus-Specific Antibody after Depletion of Memory B Cells-Reference-Cited by-同舟云学术

Persistence of Virus-Specific Antibody after Depletion of Memory B Cells

Published:2022-05-11 Issue:9 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Langley William A.¹²,Wieland Andreas¹²^ORCID,Ahmed Hasan³,Rasheed Mohammed Ata ur¹²,Davis Carl W.¹²,Sewatanon Jaturong¹²,Mueller Scott N.¹²,Shlomchik Mark J.⁴,Zarnitsyna Veronika I.²,Antia Rustom¹³,Ahmed Rafi¹²^ORCID

Affiliation:

1. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

2. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

3. Department of Biology, Emory University, Atlanta, Georgia, USA

4. Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Following vaccination or primary virus infection, virus-specific antibodies provide the first line of defense against reinfection. Plasma cells residing in the bone marrow constitutively secrete antibodies, are long-lived, and can thus maintain serum antibody levels over extended periods of time in the absence of antigen.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00026-22

Reference40 articles.

1. B cell memory: building two walls of protection against pathogens

2. Bone marrow is a major site of long-term antibody production after acute viral infection

3. Lifetime of plasma cells in the bone marrow