Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3

Author:

Luo Meng-Ting12,Mu Dan13,Yang Xiang12,Luo Rong-Hua1,Zheng Hong-Yi1,Chen Min12,Guo Ying-Qi4,Zheng Yong-Tang124ORCID

Affiliation:

1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Bio-safety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China

2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China

3. Institute of Life Sciences, Chongqing Medical University, Chongqing, China

4. National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China

Abstract

The development of animal models is critical for studying human diseases and their pathogenesis and for evaluating drug and vaccine efficacy. For improved AIDS research, the ideal animal model of HIV-1 infection should be a small laboratory mammal that closely mimics virus replication in humans.

Funder

Gansu Provincial Sci. & Tech, Department | Key Science and Technology Foundation of Gansu Province

MOST | National High-tech Research and Development Program

Chinese Academy of Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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