Low In Vitro Antifungal Activity of Tavaborole against Yeasts and Molds from Onychomycosis-Reference-Cited by-同舟云学术

Low In Vitro Antifungal Activity of Tavaborole against Yeasts and Molds from Onychomycosis

Published:2018-12 Issue:12 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abastabar Mahdi¹,Haghani Iman¹,Shokohi Tahereh¹^ORCID,Hedayati Mohammad Taghi¹^ORCID,Aghili Seyed Reza¹,Jedi Ali²,Dadashi Sulmaz²,Shabanzadeh Shafigheh¹,Hosseini Tahereh²,Aslani Narges³,Meis Jacques F.⁴⁵^ORCID,Badali Hamid¹⁶^ORCID

Affiliation:

1. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

3. Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

4. Centre of Expertise in Mycology Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

5. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

6. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

The in vitro activity of tavaborole, an FDA-approved antifungal drug, was compared to that of four antifungal agents against 170 clinical fungal isolates originating from patients with onychomycosis. Tavaborole had low activity against all isolates compared to itraconazole, terbinafine, and fluconazole, the principal choices for treatment of onychomycosis.

Funder

Merck

Mazandaran University of Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01632-18

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