Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli-Reference-Cited by-同舟云学术

Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli

Published:2006-07 Issue:7 Volume:50 Page:2573-2576
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mammeri Hedi¹,Poirel Laurent¹,Fortineau Nicolas¹,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris-Sud, 94275 Le Kremlin-Bicêtre, France

Abstract

ABSTRACT Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01633-05

Reference22 articles.

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4. Rapid and Simple Determination of the Escherichia coli Phylogenetic Group

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