Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2-Reference-Cited by-同舟云学术

Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2

Published:2009-09 Issue:9 Volume:53 Page:4007-4009
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Boumghar-Bourtchaï Leyla¹,Dhalluin Anne¹²,Malbruny Brigitte¹³,Galopin Sébastien¹,Leclercq Roland¹³

Affiliation:

1. EA 2128 Interactions Hôte et Microorganismes des Épithéliums, Université de Caen, Caen

2. UFR des Sciences Pharmaceutiques, Université de Caen, Caen, France

3. Service de Microbiologie CHU Côte de Nacre, Caen

Abstract

ABSTRACT We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01633-08

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