Affiliation:
1. Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Abstract
ABSTRACT
Adhesion of
Trichomonas vaginalis
is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the
T. vaginalis
adhesins to bind to cells of different histologic derivations and from different species has been studied. HeLa, CHO, and Vero cell lines; erythrocytes from different species; and a prokaryote without a cell wall,
Mycoplasma hominis
, were employed in order to investigate the cell specificity of the
T. vaginalis
adhesins. We observed that the
T. vaginalis
adhesins are able to bind to the different cell types to the same extent, suggesting that the host and tissue specificity of
T. vaginalis
adhesion should not be due to specificity of the parasite adhesins. Our results suggest that the data published to date on the subject are probably artifactual and that the experiments reported in the literature are not appropriate for identification of protozoan adhesins.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
24 articles.
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