Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Abstract
Our study sheds mechanistic light on how multicellular biofilm units compete to successfully colonize a eukaryote host, using
B. subtilis
microbial communities as our lens. The microbiota and its interactions with its host play various roles in the development and prevention of diseases. Using competing beneficial biofilms that are essential microbiota members on the plant host, we found that
B. subtilis
biofilms activate collective migration to capture their prey, followed by nonribosomal antibiotic synthesis. Plant hosts increase the efficiency of antibiotic production by
B. subtilis
biofilms, as they activate the synthesis of polyketides; therefore, our study provides evidence of a mechanism by which the host can indirectly select for beneficial microbiota members.
Funder
Israel Science Foundation
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Cited by
25 articles.
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