Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y-Reference-Cited by-同舟云学术

Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jiang Li¹,Samant Neha¹,Liu Ping²^ORCID,Somasundaran Mohan²,Jensen Jeffrey D.³,Marasco Wayne A.⁴,Kowalik Timothy F.⁵,Schiffer Celia A.¹,Finberg Robert W.²,Wang Jennifer P.²^ORCID,Bolon Daniel N. A.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. School of Life Sciences, Arizona State University, Tempe, Arizona, USA

4. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

5. Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Abstract

The potential for influenza A virus (IAV) to cause pandemics makes understanding evolutionary mechanisms that impact drug resistance critical for developing surveillance and treatment strategies. Oseltamivir is the most widely used therapeutic strategy to treat IAV infections, but mutations in IAV can lead to drug resistance.

Funder

DOD | Office of the Secretary of Defense

Publisher

American Society for Microbiology

Subject

Development,Geography, Planning and Development

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01982-21

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