DNAJC14-Independent Replication of the Atypical Porcine Pestivirus-Reference-Cited by-同舟云学术

DNAJC14-Independent Replication of the Atypical Porcine Pestivirus

Published:2022-08-10 Issue:15 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Reuscher Carina M.¹,Seitz Kerstin²,Schwarz Lukas³,Geranio Francesco¹,Isken Olaf⁴,Raigel Martin²,Huber Theresa¹,Barth Sandra¹,Riedel Christiane²,Netsch Anette¹,Zimmer Katharina²,Rümenapf Till²,Tautz Norbert⁴^ORCID,Lamp Benjamin¹^ORCID

Affiliation:

1. Institute of Virology, Justus-Liebig-Universität Gießen, Giessen, Germany

2. Institute of Virology, Department for Pathobiology, University of Veterinary Medicine, Vienna, Austria

3. University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria

4. Institute for Virology and Cell Biology, University of Luebeck, Lübeck, Germany

Abstract

DNAJC14 is an essential cofactor of the pestiviral NS2 autoprotease, limiting replication to tolerable levels as a prerequisite for the noncytopathogenic biotype of pestiviruses. Surprisingly, we found that the atypical porcine pestivirus (APPV) is able to replicate in the absence of DNAJC14.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01980-21

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