Affiliation:
1. Public Health Research Institute, New York, New York 10016
2. University of Ljubljana, 1000 Ljubljana, Slovenia
Abstract
ABSTRACT
ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of
Bacillus subtilis
contains a paralog of
mecA
,
ypbH
. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
38 articles.
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