Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci-Reference-Cited by-同舟云学术

Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci

Published:2006-07 Issue:7 Volume:50 Page:2583-2586
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jones Ronald N.¹²,Fritsche Thomas R.¹,Sader Helio S.¹,Ross James E.¹

Affiliation:

1. JMI Laboratories, North Liberty, Iowa 52317

2. Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

ABSTRACT Retapamulin (SB-275833), the first pleuromutilin to be developed for human topical use, was tested against a selected population of staphylococci and β-hemolytic streptococci. The MIC 90 results for retapamulin were 0.12 μg/ml for Staphylococcus aureus and ≤0.03 μg/ml for Streptococcus pyogenes ; no cross-resistance was observed for organism subsets resistant to oxacillin, erythromycin, or mupirocin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01432-05

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