In Vitro Activity and In Vivo Efficacy of Cefiderocol against Stenotrophomonas maltophilia-Reference-Cited by-同舟云学术

In Vitro Activity and In Vivo Efficacy of Cefiderocol against Stenotrophomonas maltophilia

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nakamura Rio¹^ORCID,Oota Merime¹,Matsumoto Shuhei²^ORCID,Sato Takafumi²,Yamano Yoshinori²

Affiliation:

1. Department of Anti-Infectious Drug Efficacy Evaluation Ι, Shionogi TechnoAdvance Research & Co., Ltd., Osaka, Japan

2. Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan

Abstract

Cefiderocol is a novel siderophore cephalosporin antibiotic with broad coverage against difficult-to-treat Gram-negative bacteria, including those resistant to carbapenems. Its activity against Stenotrophomonas maltophilia was investigated in vitro against clinical isolates and in lung infection models using strains either resistant (SR202006) or susceptible (SR201934, SR200614) to trimethoprim-sulfamethoxazole.

Funder

Shionogi

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01436-20

Reference24 articles.

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