Investigation of Novel pmrB and eptA Mutations in Isogenic Acinetobacter baumannii Isolates Associated with Colistin Resistance and Increased Virulence In Vivo-Reference-Cited by-同舟云学术

Investigation of Novel pmrB and eptA Mutations in Isogenic Acinetobacter baumannii Isolates Associated with Colistin Resistance and Increased Virulence In Vivo

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gerson Stefanie¹,Betts Jonathan W.²^ORCID,Lucaßen Kai¹,Nodari Carolina Silva¹³,Wille Julia¹⁴,Josten Michaele⁵⁶,Göttig Stephan⁷,Nowak Jennifer¹,Stefanik Danuta¹,Roca Ignasi⁸^ORCID,Vila Jordi⁸^ORCID,Cisneros José M.⁹,La Ragione Roberto M.²,Seifert Harald¹⁴,Higgins Paul G.¹⁴^ORCID

Affiliation:

1. Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany

2. School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

3. Universidade Federal de São Paulo–UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina–EPM, São Paulo, Brazil

4. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany

5. Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), Pharmaceutical Microbiology Unit, University of Bonn, Bonn, Germany

6. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany

7. Institute for Medical Microbiology and Infection Control, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany

8. Department of Clinical Microbiology, ISGlobal, Hospital Clínic–Universitat de Barcelona, Barcelona, Spain

9. Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocío, Seville, Spain

Abstract

Colistin resistance in Acinetobacter baumannii is of great concern and is a threat to human health. In this study, we investigate the mechanisms of colistin resistance in four isogenic pairs of A. baumannii isolates displaying an increase in colistin MICs.

Funder

Deutsche Forschungsgemeinschaft

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

EC | Seventh Framework Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01586-18

Reference48 articles.

1. Acinetobacter baumannii : Emergence of a Successful Pathogen