Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression-Reference-Cited by-同舟云学术

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Foley Sage E.¹²,Dente Michael J.³,Lei Xuqiu⁴,Sallis Benjamin F.¹²,Loew Ethan B.¹²,Meza-Segura Mario¹²,Fitzgerald Katherine A.⁴,McCormick Beth A.¹²

Affiliation:

1. Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

2. Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

3. T.H. Chan School of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

4. Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

Abstract

Preventing aberrant inflammation is essential to maintaining homeostasis in the mammalian intestine. Although P-glycoprotein (P-gp) expression in the intestine is critical for protecting the intestinal epithelium from toxins and damage due to neutrophil infiltration, its regulation in the intestine is poorly understood.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01993-22

Reference94 articles.

1. Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

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3. MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation