Affiliation:
1. Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
2. Centro de Biotecnologia, Instituto Butantan, São Paulo, Brazil
Abstract
S. aureus
is a leading cause of healthcare- and community-associated bacterial infections.
S. aureus
causes various illnesses, including bacteremia, meningitis, endocarditis, pneumonia, osteomyelitis, sepsis, and skin and soft tissue infections.
S. aureus
colonizes between 20 and 80% of humans; carriers are at increased risk for infection and transmission to others. The spread of multidrug-resistant strains limits antibiotic treatment options. Vaccine development against
S. aureus
has been unsuccessful to date, likely due to an inadequate understanding about the mechanisms of immune defense against this pathogen. The significance of our work is in illustrating the necessity of generating multipronged B-cell, Th1-, and Th17-mediated responses to
S. aureus
antigens in conferring enhanced and broad protection against
S. aureus
invasive infection, skin and soft tissue infection, and mucosal colonization. Our work thus, provides important insights for future vaccine development against this pathogen.
Funder
Takeda Pharmaceuticals U.S.A.
Publisher
American Society for Microbiology
Cited by
32 articles.
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