Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages-Reference-Cited by-同舟云学术

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Maemura Tadashi¹²,Kuroda Makoto¹,Armbrust Tammy¹,Yamayoshi Seiya²³^ORCID,Halfmann Peter J.¹,Kawaoka Yoshihiro¹²³⁴^ORCID

Affiliation:

1. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

2. Division of Virology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

3. The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan

4. Department of Special Pathogens, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01987-21

Reference30 articles.

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3. SARS-CoV-2 vaccines in development

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5. Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

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