Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis-Reference-Cited by-同舟云学术

Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Barron Madeline R.¹^ORCID,Sovacool Kelly L.²^ORCID,Abernathy-Close Lisa³^ORCID,Vendrov Kimberly C.⁴^ORCID,Standke Alexandra K.⁴,Bergin Ingrid L.⁵,Schloss Patrick D.¹^ORCID,Young Vincent B.¹⁴^ORCID

Affiliation:

1. Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

2. Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor Michigan, USA

3. Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

4. Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

5. The Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

Abstract

Patients with inflammatory bowel disease (IBD) have an increased risk of developing C. difficile infection (CDI), even in the absence of antibiotic treatment. Yet, mechanisms regulating C. difficile colonization in IBD patients remain unclear.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01904-22

Reference66 articles.

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