Persistence of Rare Salmonella Typhi Genotypes Susceptible to First-Line Antibiotics in the Remote Islands of Samoa

Author:

Sikorski Michael J.123ORCID,Hazen Tracy H.13,Desai Sachin N.2,Nimarota-Brown Susana4,Tupua Siaosi4,Sialeipata Michelle4,Rambocus Savitra5,Ingle Danielle J.6ORCID,Duchene Sebastian6,Ballard Susan A.5,Valcanis Mary5,Zufan Sara56,Ma Jianguo7,Sahl Jason W.8ORCID,Maes Mailis9,Dougan Gordon9,Thomsen Robert E.4,Robins-Browne Roy M.610,Howden Benjamin P.56,Naseri Take K.4,Levine Myron M.23,Rasko David A.13ORCID

Affiliation:

1. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

2. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

3. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

4. Ministry of Health, Government of Samoa, Apia, Samoa

5. Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

6. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

7. Department of Geographical Sciences, University of Maryland, College Park, Maryland, USA

8. Pathogen & Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA

9. Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

10. Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia

Abstract

In this study, we used whole genome sequencing and comparative genomics analyses to characterize the population structure, evolutionary origins, and genomic features of S. Typhi associated with decades of endemic typhoid fever in Samoa.

Funder

Bill and Melinda Gates Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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