Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells-Reference-Cited by-同舟云学术

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mladinich Megan C.¹²³,Conde Jonas N.¹²^ORCID,Schutt William R.¹²³,Sohn Sook-Young¹,Mackow Erich R.¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

2. Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA

3. Molecular and Cell Biology Program, Stony Brook University, Stony Brook, New York, USA

Abstract

Our findings demonstrate that CCL5 is required for ZIKV to persistently infect human brain ECs that normally protect neuronal compartments. We demonstrate that ZIKV-elicited CCL5 secretion directs autocrine hBMEC activation of ERK1/2 survival pathways via CCR3/CCR5, and inhibiting CCL5/CCR3/CCR5 responses prevented ZIKV persistence and spread.

Funder

HHS | National Institutes of Health

Turner Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01962-21

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