PspC, a Pneumococcal Surface Protein, Binds Human Factor H-Reference-Cited by-同舟云学术

PspC, a Pneumococcal Surface Protein, Binds Human Factor H

Published:2001-05 Issue:5 Volume:69 Page:3435-3437
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dave Sandhya¹,Brooks-Walter Alexis²,Pangburn Michael K.³,McDaniel Larry S.¹⁴⁵

Affiliation:

1. Departments of Microbiology,1

2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 352942; and

3. Department of Biochemistry, The University of Texas Health Science Center, Tyler, Texas 757083

4. Surgery,4 and

5. Medicine,5 The University of Mississippi Medical Center, Jackson, Mississippi 39216;

Abstract

ABSTRACT PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 ( pspC + ) and an isogenic mutant TRE108 ( pspC ). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.5.3435-3437.2001

Reference17 articles.

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5. Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif;Hammerschmidt S.;Mol. Microbiol.,2000

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