Irreversible Inhibition of Herpes Simplex Virus Replication in BSC-1 Cells by Zinc Ions-Reference-Cited by-同舟云学术

Irreversible Inhibition of Herpes Simplex Virus Replication in BSC-1 Cells by Zinc Ions

Published:1975-09 Issue:3 Volume:8 Page:377-380
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gordon Yitzhak J.¹,Asher Yael¹,Becker Yechiel¹

Affiliation:

1. Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Abstract

Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.8.3.377

Reference6 articles.

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2. Treatment of herpetic keratitis;de Roeth A.;Am. J. Ophthalmol.,1963

3. Ca", Histidine und Zn als Faktoren bei ber Riesenzellbildung durch das herpesvirus hominus;Falke B.;Z. Med. Mikrobiol. Immunol.,1967

4. Adsorption, penetration and uncoating herpes simplex virus;Hochberg E.;J. Gen. Virol.,1968

5. Zinc ions inhibit replication of rhinoviruses;Korant B. D.;Nature (London),1974

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