Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs-Reference-Cited by-同舟云学术

Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs

Published:1975-09 Issue:3 Volume:8 Page:350-355
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Davis Starkey D.¹²,Chandler John W.¹²

Affiliation:

1. Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105

2. Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington 98105

Abstract

An improved method for experimental keratitis due to Pseudomonas aeruginosa is described. Essential features of the method are use of inbred guinea pigs, intracorneal injection of bacteria, subconjunctival injection of antibiotics, “blind” evaluation of results, and statistical analysis of data. Untreated ocular infections were most severe 5 to 7 days after infection. Sterilized bacterial suspensions caused no abnormalities on day 5. Tobramycin and polymyxin B were more active than gentamicin against two strains of Pseudomonas . This model is suitable for many types of quantitative studies on experimental keratitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.8.3.350

Reference12 articles.

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2. Dissociation between results of in vitro and in vivo antibiotic susceptibility tests for some strains of Pseudomonas aeruginosa;Davis S. D.;Antimicrob. Agents Chemother.,1974

3. Activity of gentamicin, tobramycin, polymyxin B, and colistimethate in mouse protection tests with Pseudomonas aeruginosa;Davis S. D.;Antimicrob. Agents Chemother.,1975

4. Antibiotic sensitivity testing. Report of an international collaborative study;Ericsson H. M.;Acta Pathol. Microbiol. Scand.,1971

5. Finney D. J. 1964. Statistical analysis in biological assay 2nd ed. p. 524. Hafner Publishing Co. New York.

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