Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across Environmental Actinobacteria-Reference-Cited by-同舟云学术

Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across Environmental Actinobacteria

Published:2020-04-17 Issue:9 Volume:86 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Álvarez-Narváez Sonsiray¹,Giguère Steeve¹,Berghaus Londa J.¹,Dailey Cody²,Vázquez-Boland José A.³

Affiliation:

1. Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

2. Department of Epidemiology and Statistics, College of Public Health, University of Georgia, Athens, Georgia, USA

3. Microbial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom

Abstract

This study demonstrates the efficient horizontal transfer of the Rhodococcus equi conjugative plasmid pRErm46, recently identified as the cause of the emerging macrolide resistance among equine isolates of this pathogen, to and from different environmental Actinobacteria , including a variety of rhodococci as well as Nocardia and Arthrobacter spp. The reported data support the notion that environmental microbiotas may act as reservoirs for the endemic maintenance of antimicrobial resistance in an antibiotic pressurized farm habitat.

Funder

Morris Animal Foundation

University of Georgia

Horserace Betting Levy Board

Grayson-Jockey Club Research Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00108-20

Reference29 articles.