A Novel Attenuated Enterovirus A71 Mutant with VP1-V238A,K244R Exhibits Reduced Efficiency of Cell Entry/Exit and Augmented Binding Affinity to Sulfated Glycans-Reference-Cited by-同舟云学术

A Novel Attenuated Enterovirus A71 Mutant with VP1-V238A,K244R Exhibits Reduced Efficiency of Cell Entry/Exit and Augmented Binding Affinity to Sulfated Glycans

Published:2021-10-27 Issue:22 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Meng Tao¹²^ORCID,Wong Sek-Man¹²³,Chua Kaw-Bing¹

Affiliation:

1. Temasek Life Sciences Laboratory, Limited, Republic of Singapore

2. Department of Biological Sciences, National University of Singapore, Republic of Singapore

3. NUS Suzhou Research Institute, Suzhou, People’s Republic of China

Abstract

Enterovirus A71 (EV-A71) is highly contagious in children and has been responsible for thousands of deaths in Asia-Pacific region since the 1990s. Unfortunately, the virulence determinants and pathogenesis of EV-A71 are not fully clear.

Funder

Temasek Life Sciences Laboratory

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01055-21

Reference47 articles.

1. Crystal Structure of Human Enterovirus 71

2. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

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4. Molecular Comparison and Evolutionary Analyses of VP1 Nucleotide Sequences of New African Human Enterovirus 71 Isolates Reveal a Wide Genetic Diversity

5. Genetic Diversity of Enterovirus A71, India

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