Porcine Reproductive and Respiratory Syndrome Virus Infection Upregulates Negative Immune Regulators and T-Cell Exhaustion Markers-Reference-Cited by-同舟云学术

Porcine Reproductive and Respiratory Syndrome Virus Infection Upregulates Negative Immune Regulators and T-Cell Exhaustion Markers

Published:2021-10-13 Issue:21 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chaudhari Jayeshbhai¹²,Liew Chia-Sin³,Riethoven Jean-Jack M.³⁴⁵,Sillman Sarah²,Vu Hiep L. X.¹⁶^ORCID

Affiliation:

1. Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

2. School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

3. Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

4. Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

5. Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

6. Department of Animal Science, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is widespread in many swine-producing countries, causing substantial economic losses to the swine industry. Porcine alveolar macrophage (PAM) is considered the primary target for PRRSV replication in pigs.

Funder

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01052-21

Reference55 articles.

1. ICTV Virus Taxonomy Profile: Arteriviridae 2021

2. Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV)

3. The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions