Affiliation:
1. Department of Clinical Microbiology, Hygiene Institute, University of Vienna, A-1090 Vienna, Austria
Abstract
ABSTRACT
To study host response to CagA, human gastric cancer cell line AGS was infected with a
Helicobacter pylori
type I wild-type or isogenic
cagA
-negative mutant. Differentially expressed genes were identified using cDNA array technology. By Northern blotting, downregulation of focal adhesion kinase and upregulation of LIM kinase mRNA in the presence of CagA were clearly verified. Furthermore, upregulation of LIM kinase, macrophage inflammatory protein-2, c-
myc
, and bone morphogenetic protein-1 and downregulation of transcription factor Y-box binding protein-1 and focal adhesion kinase mRNA in response to
H. pylori
type I infection compared to the uninfected control could be shown by Northern blotting. Hence, these findings identified new targets for further functional studies on
H. pylori
-associated pathogenesis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
45 articles.
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