Investigation of Role of Nitric Oxide in Protection from Bordetella pertussis Respiratory Challenge-Reference-Cited by-同舟云学术

Investigation of Role of Nitric Oxide in Protection from Bordetella pertussis Respiratory Challenge

Published:2002-02 Issue:2 Volume:70 Page:679-684
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Canthaboo C.¹,Xing D.¹,Wei X. Q.²,Corbel M. J.¹

Affiliation:

1. Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG

2. Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, United Kingdom

Abstract

ABSTRACT The mechanism whereby whole-cell pertussis vaccines (WCV) confer protection against Bordetella pertussis is still not fully understood. We have previously reported that macrophage activation produced by vaccination with WCV is associated with induction of NO synthesis by macrophages in response to in vitro stimulation with B. pertussis antigens. To determine whether NO production is an effector of protection or simply a marker of activation, the susceptibility of inducible nitric oxide synthase (type II, iNOS) knockout mice to infection with B. pertussis was examined. We showed that iNOS knockout mice were more susceptible to B. pertussis respiratory challenge than wild-type mice. iNOS-deficient mice also developed a less effective protective response than wild-type mice after the same immunization with WCV. This suggests that NO plays an important role in effecting protection against B. pertussis challenge.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.2.679-684.2002

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