Affiliation:
1. Department of Medical Microbiology
2. Department of Neurology
3. Department of Virology, University of Göttingen, D-37075 Göttingen, Germany
Abstract
ABSTRACT
Guillain-Barré syndrome (GBS) is a postinfectious autoimmune polyradiculoneuropathy. The most frequent antecedent pathogen is
Campylobacter jejuni
, followed by cytomegalovirus. However, more than 40% of GBS cases currently cannot be attributed to triggering events. This might be due to the shortcomings of the serological assays used for diagnosing infections, in particular for
C. jejuni
. In our study investigating 36 patients with acute GBS, standard serological methods identified the triggering viral or bacterial etiology in only 25% of cases. However, using a highly specific enzyme-linked immunosorbent assay based on two recombinant outer antigens encoded by
C. jejuni
genes Cj0017 (P39) and Cj0113 (P18), we found serological evidence of a preceding
C. jejuni
infection in 80.6% of the patients but in only 3.5% of the controls. We conclude that the role of
C. jejuni
in triggering GBS has been greatly underestimated.
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
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