Effect of Glass on pH-Dependent Stability of Typhoid Vaccine-Reference-Cited by-同舟云学术

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Effect of Glass on pH-Dependent Stability of Typhoid Vaccine

Published:1975-08 Issue:2 Volume:2 Page:85-88
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Driesens Robert J.¹

Affiliation:

1. Lilly Research Laboratories, Greenfield, Indiana 46140

Abstract

Vaccines made from the Ty-2 strain of Salmonella typhosa were tested periodically for stability of pH and of potency. The acetone-treated cultures prepared in buffered saline solutions retained potency beyond 30 months of storage at 0 to 5 C. Similar vaccines in unbuffered saline solutions lost potency coincident with increase of alkalinity. Vaccines packaged in United States Pharmacopeia borosilicate glass vials retained potency and pH stability, whereas those in Type III United States Pharmacopeia soda-lime glass vials were less stable.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.2.2.85-88.1975

Reference15 articles.

1. American Pharmaceutical Association. 1975. General tests. Containers glass p. 818-880. In National Formulary 14th ed. Mack Publishing Co. Easton Pa.

2. Additional standards: typhoid vaccine;Department of Health, Education, and Welfare.;Fed. Reg.,1969

3. Preservation of typhoid vaccine;Henderson D. W.;Lancet,1951

4. The immunizing potency of alcohol-killed and alcohol-preserved typhoid vaccine (Felix) after storage for 15 years;Ikic D.;Bull. Res. Counc. Israel 7E,1958

5. Physiochemical properties of the VI antigen before and after mild alkaline hydrolysis;Jarvis F. G.;J. Bacteriol.,1967

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