Direct Evidence for Involvement of NF-κB in Transcriptional Activation of Tumor Necrosis Factor by a Spirochetal Lipoprotein-Reference-Cited by-同舟云学术

Direct Evidence for Involvement of NF-κB in Transcriptional Activation of Tumor Necrosis Factor by a Spirochetal Lipoprotein

Published:2000-09 Issue:9 Volume:68 Page:5447-5449
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Udalova Irina A.¹,Vidal Vincent¹,Scragg Ian G.¹,Kwiatkowski Dominic¹

Affiliation:

1. Molecular Infectious Disease Group, Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom

Abstract

ABSTRACT Variable major lipoprotein (Vmp) is a major tumor necrosis factor (TNF)-inducing component of Borrelia recurrentis , the agent of louse-borne relapsing fever. B. recurrentis Vmp rapidly stimulates nuclear translocation of NF-κB and proinflammatory cytokine gene expression in the human monocyte-like cell line MonoMac 6. By overexpressing disabled mutant IκBα in MonoMac 6 cells cotransfected with a reporter gene, we provide evidence that NF-κB is essential for the transcriptional activation of TNF in this system.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.9.5447-5449.2000

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