Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

Author:

Torriani Giulia1,Galan-Navarro Clara1,Kunz Stefan1

Affiliation:

1. Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

ABSTRACT Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.

Funder

Swiss National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference75 articles.

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