Evolution of Human Immunodeficiency Virus Type 1 in a Patient with Cross-Reactive Neutralizing Activity in Serum-Reference-Cited by-同舟云学术

Evolution of Human Immunodeficiency Virus Type 1 in a Patient with Cross-Reactive Neutralizing Activity in Serum

Published:2011-08-15 Issue:16 Volume:85 Page:8443-8448
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

van Gils Marit J.¹,Edo-Matas Diana¹,Bowles Emma J.²,Burger Judith A.¹,Stewart-Jones Guillaume B.²,Schuitemaker Hanneke¹

Affiliation:

1. Department of Experimental Immunology, Landsteiner Laboratory Sanquin Research, and Center for Infection and Immunity (CINIMA), Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands

2. Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

Abstract

ABSTRACT Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.05214-11

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