Interleukin-10 protects neonatal mice from lethal group B streptococcal infection-Reference-Cited by-同舟云学术

Interleukin-10 protects neonatal mice from lethal group B streptococcal infection

Published:1996-07 Issue:7 Volume:64 Page:2850-2852
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cusumano V¹,Genovese F¹,Mancuso G¹,Carbone M¹,Fera M T¹,Teti G¹

Affiliation:

1. Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita degli Studi di Messina, Italy.

Abstract

We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.64.7.2850-2852.1996

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