Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method-Reference-Cited by-同舟云学术

Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method

Published:2008-11 Issue:11 Volume:52 Page:4175-4177
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ostrosky-Zeichner Luis¹,Rex John H.¹²,Pfaller Michael A.³,Diekema Daniel J.³,Alexander Barbara D.⁴,Andes David⁵,Brown Steven D.⁶,Chaturvedi Vishnu⁷,Ghannoum Mahmoud A.⁸,Knapp Cindy C.⁹,Sheehan Daniel J.¹⁰,Walsh Thomas J.¹¹

Affiliation:

1. University of Texas Medical School at Houston, Houston, Texas

2. AstraZeneca, Macclesfield, Cheshire, United Kingdom

3. University of Iowa, Iowa City, Iowa

4. Duke University, Durham, North Carolina

5. University of Wisconsin, Madison, Wisconsin

6. The Clinical Microbiology Institute, Wilsonville, Oregon

7. New York State Department of Health, Albany, New York

8. Case Western Reserve University, Cleveland, Ohio

9. TREK Diagnostic Systems, Cleveland, Ohio

10. Pfizer Inc., New York, New York

11. National Cancer Institute, Bethesda, Maryland

Abstract

ABSTRACT We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00420-08

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