Possible Horizontal Transfer of the vanB2 Gene among Genetically Diverse Strains of Vancomycin-Resistant Enterococcus faecium in a Korean Hospital-Reference-Cited by-同舟云学术

Possible Horizontal Transfer of the vanB2 Gene among Genetically Diverse Strains of Vancomycin-Resistant Enterococcus faecium in a Korean Hospital

Published:2001-03 Issue:3 Volume:39 Page:1165-1168
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Lee Wee Gyo¹,Jernigan John A.²,Rasheed James K.³,Anderson Gregory J.³,Tenover Fred C.³

Affiliation:

1. Department of Clinical Pathology, Ajou University School of Medicine, Suwon, Korea1;

2. Division of Infectious Disease, Emory University School of Medicine, Atlanta, Georgia 303292; and

3. Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Abstract

ABSTRACT A total of 25 isolates of vanB -containing Enterococcus faecium were recovered from patients in a single Korean hospital over a 20-month period. There were two distinct vanB2 patterns among the 11 pulsed-field gel electrophoresis types; 17 contained the prototype vanB2 and 8 contained a novel vanB2 with a 177-bp deletion in vanY B . Both vanB2 genes were transmissible in vitro at a mean frequency of 1.1 × 10 −8 transconjugants/donor. These results suggest the horizontal spread of vanB2 is occurring among genetically diverse strains of E. faecium in Korean hospitals.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.39.3.1165-1168.2001

Reference21 articles.

1. Genetics and mechanisms of glycopeptide resistance in enterococci

2. Genetic Linkage and Cotransfer of a Novel, vanB -Containing Transposon (Tn 5382 ) and a Low-Affinity Penicillin-Binding Protein 5 Gene in a Clinical Vancomycin-Resistant Enterococcus faecium Isolate

3. Characterization of glycopeptide-resistant enterococci from U.S. hospitals

4. Heterogeneity in the vanB Gene Cluster of Genomically Diverse Clinical Strains of Vancomycin-Resistant Enterococci

5. Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR

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